This lecture by David Cochran focuses on the biological response to implants and their components. Using numerous studies, he explains the associations between the implant-abutment interface, inflammation, and bone loss. Moreover, he explains the spatial relationships between inflamed connective tissue and alveolar bone loss. He also discusses how the clinician can address this issue when selecting both the implant type and its three-dimensional placement, in particular by the use of one-piece, tissue-level implants. This presentation concludes with a discussion of three possible ways to minimize or eliminate inflammation around implants.